Elihu Hoopes and Margot Sharpe meet for the first time on 17 October 1965 at the University Neurological Institute at Darven Park, Pennsylvania. Margot is twenty-four years old, a first-year graduate student working under Professor Milton Ferris at the university’s neuropsychology laboratory. She is assigned to work on ‘Project E H’. Elihu (known as Eli), a unique amnesiac case, is a patient at the institute and the subject of their memory experiments. The Man Without a Shadow follows Margot’s devotion to the project from 1965 to 1996, through the thriving success of her career and her devastating failures in love.